Recommendations for the neurodevelopmental follow-up assessments of high-risk newborns in Switzerland were first published in 2014. Since that time, clinical advancements and new scientific evidence have necessitated an adaption of the at-risk groups, and the clinical proceedings. Meanwhile, highrisk newborns in the context of these guidelines are children who were born extremely preterm (before 28 weeks gestational age), with a congenital heart defect (CHD), requiring open-heart surgery in the first year of life, or who developed a moderate to severe hypoxic ischemic encephalopathy (cooled or not cooled) during the first hours of life. This paper presents an update of the 2014 recommendations for routin